Endocrine Abstracts

The retinoic acid receptor gamma (RARg, encoded by NR1B3/RARG) is significantly downregulated but not mutated in the MSKCC and PRAD prostate cancer (PCa) cohorts in the Cancer Genome Atlas (TCGA) data. We investigated the consequences of modifying RARg expression.Independent of ligand, stable RARg knockdown stimulated RWPE-1 and LNCaP cells proliferation, changed the cell cycle profile and significantly altered global gene expression patterns th...